Loading…
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. Pro-inflammatory cytokines, which are produced during intestinal inflammation, including Interleukin-1 (IL-1) beta (IL-1F2), Tumor Necrosis Factor alfa (TNF-alfa), and Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g), have important intestinal TJ barrier -modulating actions.
The tight junction-mediated permeability appears to be regulated by the local expression of pro-and anti-inflammatory interleukins, among which interferon-gamma and Tumor Necrosis Factor alfa (TNF-alfa) have received considerable interest
see also:
Barrier Permeability / Intestinal Permeability & Interleukin-1 (IL-1) beta (IL-1F2)
Bifidobacterium longum & Ulcerative Colitis (UC)
Escherichia coli Nissle 1917 / E. coli Nissle 1917 & Ulcerative Colitis (UC)
Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g) & Intestinal Mucosal Barrier / Mucus Layer