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Tumor antigen-specific Cytotoxic T cell (CTL) are a crucial part of the antitumor immune response but are often insufficient to eliminate tumors without help.
The reason for the weak antitumor immune response is probably the effect of negatively regulating immune checkpoints
Therefore, checkpoint blockade immunotherapies have been developed with remarkable therapeutic success. However, their effectiveness is low, and there is no evidence of a spontaneous T-cell response in patients
Ayers et al.…