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Most breast cancers carry Tn (GalNAc-O-Ser/Thr) within the same cell and in close proximity to extended glycan T (Gal beta 1,3GalNAc), with the addition of Gal to GalNAc being catalyzed by T synthase
The presence of an active T synthase suggests that the loss of the private chaperone for T synthase, COSMC, does not explain the expression of Tn (GalNAc-O-Ser/Thr) and [Sialyl-Tn (STn) / Neu5Acα2-6GalNAc-O-S…