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Bacteroides fragilis is a Gram-negative bacterium belonging to the Phylum Bacteroidetes. It regulates mucosal tolerance to self-antigens by maintaining T-cell homeostasis. It prevents the balance of CD4+ T helper cells and CD4+ Th17 cells. It induces suppressive functions of RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells. It encourages anti-inflammatory cytokines such as [interleukin-10 (IL-10)](brain://IdUJ3…