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Immune-modulating agents, anti-inflammatory agents, and glutamate antagonists represent the most intriguing potential targets for the development of new drugs for BD
Mood Stabilizers:
* Lithium: The gold standard for mood stabilization, with antimanic, antidepressant, and anti-suicide effects.
Antipsychotics: Effective in treating mania, though few are effective for bipolar depression.
Other Medications:
* Divalproex and Carbamazepine: Effective for acute mania.
* Lamotrigine: Effective for treating and preventing bipolar depression.
Antidepressants: Widely prescribed despite limited evidence for efficacy and potential for mood destabilization during maintenance treatment.
McIntyre et al. 2020 The Lancet 396:…