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Cancer Immunotherapy / Immuno-Oncology is now a central part of follicular lymphoma care, especially in relapsed/refractory disease, with the strongest recent advances coming from anti-CD20 antibodies, CD20xCD3 bispecific antibodies, and CD19-directed CAR-T therapies rather than from checkpoint inhibitors. In current practice, the most important immuno-oncology options for FL after at least two prior systemic lines are mosunetuzumab, epcoritamab, and multiple CAR-T products, with treatment selection driven by disease tempo, suspected histologic transformation, access, toxicity profile, and sequencing considerations
Flowers et al. 2018 Hematology Am Soc Hematol Educ Program 2018(1): 194-19…