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An initial antibiotic screen in Firmicutes revealed that c-di-AMP production was largely driven by antifolate antibiotics targeting dihydrofolate reductase (DHFR), which promotes folate regeneration required for thymidine biosynthesis
Tang et al. 2022b Cell Host & Microbe 30(7): 961-974
Thymidine metabolism disruption in Firmicutes leads to elevated c-di-AMP-mediated [STING](brain://RxlIJGjQb16nwINGjnOwTQ/StingStimulatorOfInterfe…