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Concerning Topotecan & Small-Cell-Lung-Cancer (SCLC), Topotecan is a chemotherapy drug that has shown significant activity in the treatment of small-cell lung cancer (SCLC), particularly in patients sensitive to prior chemotherapy. It has been found to be effective as a second-line treatment for SCLC, with predictable and manageable toxicity.
A systematic review and meta-analysis of 1347 patients concluded that topotecan is the most reliable chemotherapy regimen for relapsed SCLC, providing a possibly promising outcome for sensitive-relapse SCLC patients (1).
Topotecan has received approval from both the FDA an…