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Primary sclerosing cholangitis (PSC]) is a rare chronic cholestatic disease with heterogeneous phenotypes that may lead to liver transplantation and/or end-stage liver disease
Its multifactorial etiopathogenesis remains uncertain, but gut-liver axis, bile composition, and excretion are widely demonstrated to influence the immune-mediated fibrogenic reactive cascade
Primary biliary cholangitis (PBC) is a rare, chronic, autoimmune liver disease with increasing prevalence worldwide. It predominantly affects women aged 40 and over and is characterized by the destruction of the interlobular bile ducts with cholestasis.
Lv et al. 202…