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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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3-Hydroxypropionate / 3-Hydroxypropionic acid

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The conjugation of 3-Hydroxypropionate / 3-Hydroxypropionic acid to amino acids (3HP-AAs) and the excretion of both 3-Hydroxypropionate / 3-Hydroxypropionic acid and 3HP-AAs suggested that 3-Hydroxypropionate / 3-Hydroxypropionic acid may be toxic at high levels
Fox et al. 2022 Nature 607: 571

3-Hydroxypropionate / 3-Hydroxypropionic acid is an intermediate in the propionate shunt pathway, which is activated when flux through the canonical, vitamin-B12 -dependent propionate breakdown pathway is perturbed
Watson et al. 2016 eLife 5: e17670…

References (Sources)

C. elegans as a model for inter-individual variation in metabolism
Fox et al. 2022 Nature 607: 571
Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans
Watson et al. 2016 eLife 5: e17670

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3-Hydroxypropionate / 3-Hydroxypropionic acid

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