Colorectal Cancer (CRC) (Mismatch Repair Deficiency (MMR-d) / DNA Mismatch Repair / Microsatellite Instability (MSI))

Colorectal Cancer (CRC), specifically the subtype associated with Mismatch Repair Deficiency (MMR-d) or Microsatellite Instability (MSI), is defined by a high frequency of mutations in the DNA mismatch repair genes . When there are defects in this repair system, it results in frameshift mutations. These mutations lead to the creation of frameshift immunogenic peptides, which act as neoantigens. These neoantigens stimulate the anti-tumor immune response, contributing to a more favorable prognosis and an improved response to immunotherapies.
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