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Beta-catenin binds to the cytoplasmic part of cadherins (to the catenin-binding domain) and thus forms a bridge between cadherin and alfa-catenin. Beta-catenin also serves as a signaling molecule in the Wnt signaling pathway. It is transported into the cell nucleus and acts there as a component of a transcription factor. This is probably also the cause of increased beta-catenin concentrations in certain tumors.
Beta-catenin is a transcriptional co-activator that relies on T cell factor (TCF) …