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Two different subpopulations of intestinal Foxp3+ Tregs are characterized by their expression of the transcription factors Zinc Finger Protein Helios (IKFZ2) or RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3). There is a homeostatic balance between the two. The mechanisms that regulate the homeostatic balance between Zinc Finger Protein Helios (IKFZ2)+ Foxp3+ Colonic Treg cells and [RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells](brain://bUYF7Ilm3ka4RTZ6J2iQkg/RARrelatedOrphanReceptorGammaTRORgammatIsoform2NR1F3…