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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)

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Naive CD4+ T Cells

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Naive CD4+ T Cell Activation Through CD40L

Naive CD4+ T cells upregulate CD40L after interacting with CD70. CD70 is expressed on CD8+ T cells after interaction with dendritic cells. CD40L has a critical role during the priming phase of adaptive immune responses in lymph nodes (1, 2)

Naive CD4+ T Cell States and Gene Activity

Naive CD4+ T cells in mice are not uniform. They form several groups with distinct gene-activity patterns associated with:

Cellular resting state

Extracellular matrix and cytoskeleton biology

Type I inte…

References (Sources)

Conversion of peripheral CD4+CD25 naive T cells to CD4+ CD25 + regulatory T cells by TGF-β induction of transcription factor Foxp3
Chen et al. 2003 J. Exp. Med. 198: 1875-1886
Distinct regulatory CD4*T cell subsets, differences between naive and antigen specific T regulatory cells
Hall et al., 2011
Frequency of Epitope-Speciﬁc Naive CD4 + T Cells Correlates with Immunodominance in the Human Memory Repertoire
Kwok et al., 2012
IL-1ß Enhances CD40 Ligand-Mediated Cytokine Secretion by Human DC: A Mechanism for T Cell-Independent DC Activation
Luft et al. 2002
Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters
Stuhler et al. 1999 Proc Natl Acad Sci USA 96: 1532
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-b–Mediated Tumor Immune Evasion
Ibrahim et al., 2018
The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
Even et al. 2024 Immunity 57(8): 1893-1907

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