Multidrug-resistant (MDR) Pseudomonas aeruginosa

Concerning MDR Pseudomonas aeruginosa, Pseudomonas aeruginosa is a big problem for public health because it naturally resists antibiotics and can also develop resistance over time (1, 2).

Pseudomonas aeruginosa employs several mechanisms to resist antibiotics, making it a formidable pathogen. These mechanisms include:

• Efflux Pumps and Reduced Permeability: These strategies help the bacterium expel antibiotics and limit their entry, respectively.


• Genetic Adaptations: Resistance is acquired through mutations and horizontal gene transfer.


• Adaptive Strategies: The formation of biofilms and the use of [quorum sensing](brain:…