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Agonists (listed in the box above) lead to dimerization to the heterodimer of TLR-1 and TLR-2. The dimerization of TLR-1 and TLR-2 brings the cytoplasmic TIR (Toll IL-1 receptor) domain of the TLR chains into close proximity to initiate signaling.
The two adapter molecules, TIR domain-containing adapter protein (TIRAP) and [Myeloid Differentiation Primary Response 88 (MY…