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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Inflammatory Bowel Disease (IBD) & Intestinal mucosal macrophages

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Contents

Abnormal activation of macrophages plays a role in the immunopathogenesis of inflammatory bowel disease (IBD). Oncostatin M is responsible for causing intestinal inflammation and can predict how patients with inflammatory bowel disease will respond to tumor necrosis factor-neutralizing therapy.
West et al. 2017 Nat. Med. 23, 579–589
Martin et al. 2019 Cell 178: 1493-1508
Aschenbrenner et al. 2020 Gut 70: 1023-1036
Castro-Dopico et al. 2020 Cell Rep 32: 107857
Gaiani et al. 2020 Sci Rep 10: 12238

The reduction of macrophages led to decreased infl…

References (Sources)

Deconvolution of monocyte responses in inﬂammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
Aschenbrenner et al. 2020 Gut 70: 1023-1036
Disordered macrophage cytokine secretion underlies impaired acute inﬂammation and bacterial clearance in Crohn’s disease
Smith et al. 2009 J Exp Med 206: 1883-1897
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inﬂammation
Castro-Dopico et al. 2020 Cell Rep 32: 107857
Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor
Redhu et al. 2017 Elife 6: e27652
Monocytes from inﬂiximab-resistant patients with Crohn’s disease exhibit a disordered cytokine proﬁle
Gaiani et al. 2020 Sci Rep 10: 12238
Oncostatin M drives intestinal inﬂammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inﬂammatory bowel disease
West et al. 2017 Nat. Med. 23, 579–589
Single-Cell Analysis of Crohn’s Disease Lesions Identiﬁes a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy
Martin et al. 2019 Cell 178: 1493-1508

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