Inflammatory Bowel Disease (IBD) & Intestinal mucosal macrophages

How does gut macrophage dysregulation contribute to chronic inflammation and loss of intestinal tolerance in inflammatory bowel disease (IBD)?

The dysregulation of gut macrophages has been shown to act as a chronic inflammatory trigger for inflammatory bowel disease (IBD). This condition results in the loss of intestinal tolerance to both commensal bacteria and food antigens (1).

Can Oncostatin M Predict Anti-TNF Treatment Response in Inflammatory Bowel Disease?

Abnormal activation of macrophages plays a role in the immunopathogenesis of inflammatory bowel disease (IBD). Oncostatin M is responsible for causing intestinal inflammation and can predict how patients with [inflammatory bowel dise…