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The number and phenotype of macrophages are closely related to tumor growth and prognosis.
Macrophages are recruited to (and polarized at) the tumor site, promoting tumor growth, stimulating tumor angiogenesis, facilitating tumor cell migration, and creating a favorable immunosuppressive TME.
Macrophages remodel the TME through interactions with other cells.
Tumor‑associated macrophages can be a new target for antitumor therapies.
Xu et al. 2022 Int J Oncology 60: 57…