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It is known for its ability to produce high amounts of the short-chain fatty acid butyrate. Therefore, it is used as a live biotherapeutic probiotic product in clinical settings.
CBM588 is a strain of Clostridium butyricum, a Gram-positive bacillus which produces short-chain fatty acids. It promotes the growth of commensal gut bacteria like Bifidobacterium, Lactobacillus and Bacteroides spp, and has been shown to enhance Th1 cells and IL-10 production with immunomodulatory effects.
Bergerot et al. 2020 Journal of Clinical Oncology 38(6): https://doi.org/10.1200/JCO.2020.38.6_suppl.TPS764
Conventional mice colonized with C. butyricum CBM 588 increased the number of both [I…