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High ST6Gal 1 Sialyltransferase (ST6Gal-I)-I expression, a specific protein marker, has been identified as a significant factor that can independently predict unfavorable outcomes in patients diagnosed with Clear Cell Renal Cell Carcinoma (ccRCC). This protein's overexpression is associated with a higher risk of both reduced survival rates and increased chances of cancer recurrence. Notably, the prognostic significance of elevated ST6Gal-I levels is particularly pronounced in individuals categorized as having low to intermediate-risk disease according to the University of California Los Angeles Integrated Staging System (UISS) score. This finding underscores the potential utilit…