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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Glycans & Immunity

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Glycans play a crucial role in the immune system, with a rich history in immunology. Key areas include:

Human ABO(H) and Lewis blood groups

Lectin pathway of complement

Leukocyte trafficking via selectin–glycan interactions

Zhou et al. 2018a

Recent advancements in glycobiology technologies have highlighted the significance of glycans in clinical settings and therapeutics. Notable examples include:

IgG glycosylation affecting biologic drug function

HIV glycan recognition aiding in the development of broadly neutralizing antibodies (bnAbs)

Receptors like Galectins and Siglecs are involved in cancer i…

References (Sources)

Glycans as key checkpoints of T cell activity and function
Pereira et al. 2018 Front Immunol 9: 2754
Review
The Glycoscience of Immunity
Zhou et al. 2018a
Review

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Glycans & Immunity

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