Vancomycin & Adiposity / Obesity

Clinical data:

The randomized, placebo-controlled, double-blind clinical basic science trial NCT02241421 revealed that the use of antibiotics did not influence tissue-specific insulin sensitivity, energy or substrate metabolism, postprandial hormones and metabolites, systemic inflammation, gut permeability, or the size of adipocytes. Notably, even at the 8-week follow-up, there were no changes in energy harvest, adipocyte size, or overall insulin sensitivity, despite a significantly altered microbial composition. This suggests that a 7-day course of antibiotics, which disrupts the adult microbiota, does not have a clinically significant effect on the metabolic health of obese individuals (1)

References:

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