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The colonic epithelium is hypoxic (1, 4). Dysbiosis is linked to an increase in facultative anaerobic Proteobacteria (1, 2, 3, 4). So, Proteobacteria presence may serve as a diagnostic signature for disease risk (3, 4).
Intestinal inflammation or antibiotic treatment raises epithelial oxygenation in the colon (1, 4). Increased oxygenation disrupts anaerobiosis (1, 4). This disruption leads to a dysbiotic expansion of facultative anaerobic Proteobacteria through aerobic respiration (1, 4)
(1)
(2)
(3) Kim et al. 2017 Immunol Rev. 279(1): 90-105
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