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Lurbinectedin is a medication used to treat adults with metastatic small cell lung cancer (SCLC) whose disease has progressed after platinum-based chemotherapy. It is a synthetic tetrahydropyrrolo [4,3,2-de]quinolin-8(1H)-one alkaloid analogue that covalently binds to residues in the minor groove of DNA, leading to delayed progression through the cell cycle and ultimately cell death
Lurbinectedin is a cytotoxic agent that belongs to the group of alkylating agents, which bind to specific DNA structures
It was approved for medical use in the United States in June 2020
Lurbinectedin is administered intravenously and is indicated for patients who have limited treatment options
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