Farnesoid X receptor (FXR / NR1H4)

Dimer: NR1H/RXR

The Farnesoid X receptor (FXR / NR1H4) is a ligand-induced transcription factor and a member of the nuclear receptor (NR) superfamily.

• Identified in 1999 as a bile salt-activated transcription factor.


• Plays a crucial role in various physiological processes.


• Essential for regulating intestinal innate immunity and homeostasis.

Farnesoid X receptor (FXR / NR1H4) was identified as a cell surface receptor for bile salts and they co-expressed in the enteroendocrine L cells.

References:

1. Miyata et al. 2021


2. Schubert et al. 2017 Immunological Reviews 279: 23-35


3. Fiorucci et al. 2009 Trends Pharm. Sci. 30: 570-580


4. Vavassori et al. 2009 J. Immunol. 183: 6251–6261

see also:
Metabolic Syndrome (MetS)