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Bacteroides strongly correlates with the beta-glucuronidase level
The metabolism of a hundred medications is possibly altered by microbial beta-glucuronidase.
Even though the human microbiota is complex, scientists haven't exactly pinpointed which Beta-glucuronidases are responsible for reactivating drugs using proteomics.
Beta-glucuronidases are broadly distributed in commensal bacteria and are present in humans, inhibitors need to be selective for bacterial beta-glucuronidases and nontoxic to both host cells and other gut microbes.
Structural studies revealed th…
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