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Fibroblast growth factor receptor 3 (FGFR3) mut and their ligands, fibroblast growth factors (FGFs) are involved in several pathological processes including cancer.
Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic fusions. Thus, the development of FGF/FGFR-targeting therapies is the focus of several basic, preclinical, and clinical studies.
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