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Cancers such as intrahepatic cholangiocarcinoma (ICCA) have demonstrated alterations of FGFR allowing unregulated growth.
Clinically FGFR fusions and mutations are relatively common and therapeutic targets in solid tumors such as urothelial carcinoma, intrahepatic cholangiocarcinoma, lung cancer, hepatocellular carcinoma, breast cancer and gynecological cancers.
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