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Regenerative therapies have emerged as a promising approach to address the function of dysfunctional or dedifferentiated Pancreatic Beta Cells, ultimately aiming to correct the impaired insulin secretion characteristic of diabetes. The beta cells face immense pressure to produce insulin at unsustainable levels, especially during the onset of the disease, which places a significant strain on their secretory machinery. This heightened demand often leads to Endoplasmic reticulum stress, a condition where the Endoplasmic reticulum (ER) struggles to cope with the folding and processing of proteins.
Chronic and unresolved…