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The naturally occurring antimicrobial peptide Protegrin-1 (PG-1) is an 18-amino acid peptide containing two disulfide bridges
Protegrin-1 (PG-1) is described as rapidly bactericidal in vitro. It is capable of reducing the number of viable colony-forming units (CFU) of bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa by more than 99.9% within minutes at concentrations near its minimum inhibitory concentration (MIC), indicating that it typically kills susceptible microorganisms very quickly once contact is made
Steinber…