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A diet high in fructose has become a significant dietary risk factor for developing metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease.
In terms of metabolism, when there is an excess of fructose, it is quickly phosphorylated by the enzyme ketohexokinase (KHK). This process depletes intracellular ATP and leads to the overproduction of uric acid and [reactive oxygen species (ROS)](brain://YukFAbK_UkGBGXPcRslYRw/OxidativeStressRea…