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GPC‑3 is a membrane‑bound heparan sulfate (HS) proteoglycan that belongs to the glypican family.
It anchors at the glycosylphosphatidylinositol (GPI) of the membrane by the C‑terminus.
It can be enzymatically lysed, releasing a soluble form of GPC‑3; and is released into the serum by a lipase called notum