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Pre- or even clinical investigations target specific state-associated microglial properties and functions (e.g., inflammatory activity, phagocytosis, proliferation, metabolism, or surveillance).
Šimončičová et al. 2022 Trends in Pharmacological Sciences, August 43(8): 669
Recent analyses of human brain samples reveal striking changes in microglial and astrocyte transcriptomes in response to various diseases, infections, and trauma.
During disease, infection, and after trauma, microglia and astrocytes exhibit altered gene expression profiles that are predicted to affect their function and thereby the health of neurons and other CNS cells; however, there is still a large gap between specific transcriptional states and …