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CONCLUSION:
Detergents are highly effective antimicrobial agents used to decontaminate surfaces infected with deadly pathogens.
APOL3 is an IFN-gamma-stimulated host defense protein that has developed a potent detergent-like activity to protect human cells from bacteria.
APOL3 works with other host ISGs against the double membrane of gram-negative bacteria - a huge barrier to resistance.
Antibacterial agents that break down this barrier during infection, such as APOL3, are naturally found in human cells.…