Activation / Activators & Group 3 ILCs (ILC3)

Research by Serafini et al. (2022) has shed light on the behavior of Group 3 ILCs (ILC3) when they encounter bacteria such as Citrobacter rodentium. The findings indicate that ILC3s undergo a "training" process upon initial contact with these bacteria. This training keeps the ILC3s activated for a prolonged period, allowing them to maintain their enhanced state for several months.

When these trained ILC3s are exposed to the same bacteria again, they not only multiply more efficiently but also show stronger responses involving Interleukin-22 (IL-22), a crucial mediator of the [immune response](brain://5QFzqPH_7kiBWucrMxK3ow/ImmuneR…