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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Cholestenone

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Cholestenone, also known as 4-cholesten-3-one, is an oxidized derivative of cholesterol. Cholestenone is produced during Mycobacterium tuberculosis infection. The bacterium induces the accumulation of cholestenone in infected macrophages through the action of its enzyme 3β-hydroxysteroid dehydrogenase (3β-Hsd)
Chandra et al. 2022 J Clin Invest. 132(3): e152509
Roth et al. 2024 Immunometabolism (Cobham) 6(2): e00042

This metabolite is not a significant human metabolite, making it a potential biomarker for diagnosing Tuberculosis (TB) in clinical samples
Chandra et al. 2022 J Clin Invest. 132(3): e152509

Cholestenone has been found to exhibit antibiotic act…

References (Sources)

Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL
Kobayashi et al. 2021 Proc Natl Acad Sci USA. 118(16): e2016469118
Cholesterol to cholestenone oxidation by ChoG, the main extracellular cholesterol oxidase of Rhodococcus ruber strain Chol-4
Fernández de Las Heras et al. 2014 J Steroid Biochem Mol Biol. 139: 33-44
Macrophage global metabolomics identifies cholestenone as host/pathogen cometabolite present in human Mycobacterium tuberculosis infection
Chandra et al. 2022 J Clin Invest. 132(3): e152509
The role of cholesterol and its oxidation products in tuberculosis pathogenesis
Roth et al. 2024 Immunometabolism (Cobham) 6(2): e00042
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