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Mucin 1 (MUC1) is a membrane‐bound, highly glycosylated protein that is overexpressed in all stages of malignant transformation.
Overexpression of MUC1, together with loss of polarization and hypoglycosylation, are associated with resistance to apoptosis, which is the process that results in the efficient removal of damaged cells.
Inhibition of the apoptotic process is responsible for tumor development, tumor progression, and drug resistance.
MUC1 is considered an oncogenic molecule involved in various signaling pathways responsible for the regulation of apoptosis. …