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Microbiome-based therapeutics might help with diarrhea caused by immune checkpoint inhibitors (ICI). This is especially true when the diarrhea is due to immune-mediated colitis. However, the best evidence we have is for fecal microbiota transplantation (FMT). This is mainly for cases that don't respond to steroids or other treatments. Routine use of probiotics isn't as well-supported. Reviews often mention that the gut microbiota plays a role in ICI-related diarrhea and colitis. They also highlight FMT, probiotics, and…