OX86

OX86 refers to a mouse anti-OX40 antibody that has been studied as an agonist for its role in mediating antitumor effects.

Research has shown that OX86 administration can lead to the depletion of intratumoral regulatory T cells in an activating-FcγR dependent manner, which correlates with tumor regression
Bulliard et al. 2014
Bulliard et al. 2014a Immunol Cell Biol. 92(6): 475-80

Additionally, OX86 has been reported to inactivate regulatory T cells, facilitate tumor rejection, and induce antitumor immunity when combined with other therapeutic agents or antibodies
Piconese et al. 2008 J Exp Med. 205(4): 825-39
Hirschhorn-Cymerman et al. 2009 J Exp Med. 206(5): 1103-16

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