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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Butyrate / Butyric acid & Goblet cells

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.In mouse and human cell lines, insufficient butyrate can cause the mucin-producing goblet cells to switch from beta-oxidation to anaerobic glycolysis, which negatively affects goblet cell differentiation and the synthesis of MUC2
Wolter et al. 2021 Nat Rev Gastroenterol Hepatol 18(12): 885-902

Butyrate stimulates goblet cells to produce mucins
Chen & Vitetta 2020 Immune Netw. 20(2): e15

In a chick…

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii inﬂuence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
Wrzosek et al. 2013 BMC Biol. 11: 61
Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens
Sikandar et al. 2017 Asian-Australas J Anim Sci 30: 690-699
KLF4 regulation in intestinal epithelial cell maturation
Flandez et al. 2008 Exp Cell Res 314: 3712-3723
Leveraging diet to engineer the gut microbiome
Wolter et al. 2021 Nat Rev Gastroenterol Hepatol 18(12): 885-902
Review
The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation
Chen & Vitetta 2020 Immune Netw. 20(2): e15
Review
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
Katz et al. 2002 Development 129: 2619-2628

7/1/2026