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Formate C-acetyltransferase (pflB) may serve as one of the key enzymes responsible for Indole-3-carbinol (I3C) generation in Bifidobacterium.
Indole-3-carbinol (I3C) was proven to act as a natural inhibitor of Cytochrome P450 2E1 (CYP2E1) and exerted protective effects against Acute liver failure (ALF).
Indole-3-carbinol (I3C) and its major in vivo product, 3,3′-Diindolylmethane (DIM), are effective cancer [chemopreven…