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Bacteroides thetaiotaomicron colonizes the gut and produces beta-galactosidase. This leads to presentation on human leukocyte antigen (HLA)-DQB1 by antigen-presenting cells. Local CD4+ T cells get activated and differentiate into CD4+ Th17 cells. These Th17 cells enter the heart muscle. An unknown inflammatory trigger occurs. Myosin heavy chain 6 (MYH6) is recognized by these CD4+ Th17 cells and autoimmune myocarditis is triggered
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