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Cancer cells hijack tumor-associated macrophages to sustain their outgrowth. The IKZF1–IRF4/IRF5 axis seems to be a key molecular pathway regulating macrophage polarization in multiple myeloma. These results suggest targeting Ikaros Family Zinc Finger 1 (IKZF1) could provide a new strategy to reprogram myeloma-associated macrophages toward a tumoricidal and immune-activating phenotype.
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