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The colonic microbiota are responsible for fermenting dietary fibers, which results in the production of short-chain fatty acids. Recent studies indicate that one of these fatty acids, propionate, might have a significant impact on regulating appetite. Our hypothesis was that delivering propionate directly to the colon would lead to an increase in the secretion of peptide YY (PYY) and [glucagon-like peptide-1 (GLP-1)](brain:/…