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Most prostate cancers are at least initially androgen-dependent, meaning they rely on androgens such as testosterone and dihydrotestosterone to grow, which is why androgen-deprivation therapy and androgen-receptor blockade are standard treatment approaches in many settings. The usual term is hormone-sensitive or castration-sensitive prostate cancer. The NCI defines this as prostate cancer that needs androgens to grow and therefore stops growing when androgens are not present or their action is blocked
Metastatic castration-resistant prostate cancers have enriched DNA repair gene defects (DRDs) that can be possibly treated by inhibiting PARP proteins
Smith et al. 2022 The Lance…