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Prostate cancer is the most common carcinoma among older males in Western countries (4) and the fifth leading cause of cancer-related death among men, with most deaths linked to metastatic disease (2). Prostate cancer deaths in the US: 33,720 in 2011; incidence: 240,890 in 2011(6). Estimated prostate cancer deaths in the United States: 28,170 in 2012 (5).
High expression of androgens and androgen receptors is closely related to prostate cancer (4). Therefore, most prostate cancers are initially androgen-dependent, relying on androgens like testosterone and dihydrotestosterone for growth (1). The NCI defines hor…