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An emerging therapeutic target is microRNA (miRNA), Small non-coding RNAs (sncRNA) that negatively regulate sets of proteins. Their multitargeting action offers unique advantages for certain forms of epilepsy with complex underlying pathophysiology, such as temporal lobe epilepsy (TLE).
The blood–brain barrier is an obstacle in delivering antisense oligonucleotides (ASOs) as therapies in neurological disease, and ASOs currently have to be administered by direct central injection.
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