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Arginase I is the dominant isoform in the cytoplasm of the mainly liver and is vital for detoxifying ammonia via the urea cycle. Arginase I serves as a metabolic, immunological, and therapeutic target in a variety of physiological and pathological processes, particularly in metabolism, immunomodulation, and oncology (1, 2, 3)
Arg1 is expressed in myeloid cells, including neutrophils and macrophages, where it regulates immune responses via [arginine m…