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Caspase-9 is activated by cytochrome c, which is found in the mitochondria of normal cells. This is called activation of the intrinsic apoptosis pathway.
After cytochrome c exits through pores in the mitochondrial membrane into the cytosol, it binds to Apoptotic protease activating factor 1 (Apaf-1).
This induces self-assembly of the multimeric protein complex called the apoptosome, which recruits Pro-Caspase 9. The [apoptosome](brain://FFG6fcO7KUu2x33-Hsoyhg/Apopt…