Colitis / Intestinal Inflammation & Interleukin-23 (IL-23)

Chronic inflammatory disorders such as inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) are caused by lymphocytes that are inappropriately activated and destroy self-tissues. Recent data have assigned a disease-promoting role to Interleukin-23 (IL-23), a cytokine of the Interleukin-12 (IL-12) family
Duerr et al. 2006 Science 314: 1461-1463
Izcue et al. 2009 Annu Rev Immunol 27: 313-338

IL-23 Deﬁciency or blockade protects from human [IBD](brain://Npyo13gOo0idTQuOpA…

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
Duerr et al. 2006 Science 314: 1461-1463
Characterization of FOXP3 + CD4 + Treg cells in Crohn’s disease
Saruta et al. 2007 Clin. Immunol. 125: 281–90
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
Kullberg et al. 2006 J Exp Med 203: 2485-2494
IL-23/IL-17 immunity as a hallmark of Crohn’s disease.
Hölttä et al. 2008 Inﬂamm. Bowel Dis. 14: 1175–84
Increased expression of interleukin 17 in inﬂammatory bowel disease
Fujino et al. 2003 Gut 52: 65–70
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
Hue et al. 2006 J Exp Med 203: 2473-2483
Regulatory lymphocytes and intestinal inflammation
Izcue et al. 2009 Annu Rev Immunol 27: 313-338
Review